SGEM#297: tPA Advocates Be Like – Never Gonna Give You Up

Studi estratti dal podcast di Dr. Ken Milne

• 2020ECASS IIIAnticoagulation & AntithromboticsIn 821 patients with acute ischaemic stroke treated 3-4.5 hours after onset, alteplase did not improve 90-day disability-free survival compared with placebo.
• 2008ECASS IIIAnticoagulation & AntithromboticsIn 821 patients with acute ischaemic stroke 3 to 4.5 hours after onset, intravenous alteplase increased freedom from disability at 90 days compared with placebo.
• 1995NINDS rt-PA Stroke StudyAnticoagulation & AntithromboticsIn 624 patients with acute ischaemic stroke within 3 hours of onset, intravenous t-PA improved disability-free outcome at 3 months compared with placebo.
• 2009A Graphic Reanalysis of the NINDS TrialAnticoagulation & AntithromboticsIn 624 patients with acute ischaemic stroke, graphic reanalysis showed tissue plasminogen activator gave 90-day neurologic outcomes similar to placebo.
• 2012IST-3Anticoagulation & AntithromboticsIn 3035 patients with acute ischaemic stroke within 6 h of onset, intravenous alteplase did not increase survival free of disability compared with control.