SGEM Xtra: COVID19 Treatments – Be Skeptical

Studien extrahiert aus dem Podcast von Dr. Ken Milne

• 2020Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patientsInfection & AntimicrobialsIn 80 patients with mostly mild COVID-19, hydroxychloroquine plus azithromycin was given without a comparator, and all but two improved clinically.
• 2020Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019Infection & AntimicrobialsIn 150 patients hospitalised with mainly mild to moderate COVID-19, hydroxychloroquine did not raise 28 day viral clearance compared with standard care alone.
• 2020Rapid Systematic Review of Chloroquine and Hydroxychloroquine as Treatment for COVID-19Infection & AntimicrobialsAcross seven completed trials in patients with COVID-19, chloroquine or hydroxychloroquine improved virologic or clinical outcomes in five, compared with standard care.
• 2020Compassionate Use of Remdesivir for Patients with Severe Covid-19Infection & AntimicrobialsIn 53 patients hospitalised with severe Covid-19, compassionate-use remdesivir was followed by improved oxygen support in 68%, with no control group.
• 2020Remdesivir in adults with severe COVID-19Infection & AntimicrobialsIn 237 adults admitted to hospital with severe COVID-19, intravenous remdesivir did not shorten time to clinical improvement compared with placebo.
• 2020ACTT-1Infection & AntimicrobialsIn 1062 adults hospitalised with Covid-19 and lower respiratory tract involvement, remdesivir shortened time to recovery compared with placebo.
• 2021CONCOR-1Infection & AntimicrobialsIn 940 hospitalized adults with COVID-19 receiving oxygen, convalescent plasma did not reduce intubation or death by 30 days compared with standard of care.
• 1816Dissertatio Medica Inauguralis de Synocho Castrensi (Hamilton's bloodletting comparison)Infection & AntimicrobialsIn 366 soldiers with camp fever, bloodletting raised mortality to 29% versus 2.5% with treatment without the lancet.