SGEM#259: Eat for Two – If I Didn’t have Nausea and Vomiting of Pregnancy

Trials extracted from the podcast by Dr. Ken Milne

• 2018Association of Maternal First-Trimester Ondansetron Use With Cardiac Malformations and Oral Clefts in OffspringOtherIn 1.8 million pregnancies, first-trimester ondansetron did not increase cardiac or overall malformations but slightly increased oral clefts versus no exposure.
• 2014Use of ondansetron during pregnancy and congenital malformations in the infantOtherIn1,349 infants of women who tookondansetronin early pregnancy, the risk ofcardiac septum defectswas higher than inunexposed pregnancies.
• 2013Ondansetron use in early pregnancy and the risk of congenital malformationsOtherIn 897,018 Danish births, ondansetron in early pregnancy was associated with more cardiac malformations than no ondansetron exposure.
• 2013Ondansetron in Pregnancy and Risk of Adverse Fetal OutcomesOtherAmong608,385 Danish pregnancies,ondansetron exposurewas not associated withspontaneous abortion, stillbirth, major birth defects or preterm birthcompared withno ondansetron