SGEM Xtra: Walk of Life – Thrombolysis for Acute Ischemic Stroke

Ensaios extraídos do podcast de Dr. Ken Milne

• 2016Intravenous thrombolysis for presumed acute ischaemic stroke: a systematic reviewAnticoagulation & AntithromboticsIn 10 431 patients with presumed acute ischaemic stroke,intravenous thrombolysisimproved functional outcome versuscontrolbut increasedhaemorrhage and death
• 2014Intravenous thrombolysis with alteplase for acute ischaemic stroke: IPD meta-analysisAnticoagulation & AntithromboticsIn 6756 patients with acute ischaemic stroke, intravenous alteplase increased disability-free survival at 3-6 months compared with control.
• 2014Thrombolysis for acute ischaemic stroke (Cochrane systematic review)Anticoagulation & AntithromboticsIn 10,187 patients with acute ischaemic stroke, thrombolytic therapy reduced death or dependency at three to six months compared with control.
• 1995NINDS rt-PA Part 2Anticoagulation & AntithromboticsIn333 patients with acute ischemic stroke treated within three hours of onset,intravenous alteplaseincreasedfavorable functional outcome at three monthscompared withplacebo
• 2008ECASS IIIAnticoagulation & AntithromboticsIn 821 patients with acute ischaemic stroke treated 3 to 4.5 hours after onset, intravenous alteplase improved freedom from disability at 90 days compared with placebo.
• 2012IST-3Anticoagulation & AntithromboticsIn 3035 patients with acute ischaemic stroke, intravenous alteplase within 6 h did not significantly increase survival free of disability compared with control