SGEM#208: It Makes No Difference – Glucocorticoids for the Treatment of Septic Shock

Essais extraits du podcast de Dr. Ken Milne

• 2018ADRENALICU & Critical CareIn 3800 ventilated adults with septic shock, hydrocortisone infusion did not lower 90-day all-cause mortality compared with placebo.
• 2002Low-dose hydrocortisone and fludrocortisone in septic shockICU & Critical CareIn 300 adults with septic shock, hydrocortisone plus fludrocortisone reduced 28-day mortality in relative adrenal insufficiency compared with placebo.
• 2008CORTICUSICU & Critical CareIn499 adults with septic shock,hydrocortisonedid not reduce28-day mortalitycompared withplacebo.
• 2016HYPRESSICU & Critical CareIn 380 adults with severe sepsis but not in septic shock, hydrocortisone did not prevent septic shock within 14 days compared with placebo.