SGEM#113: EGDT – ProMISe(s) ProMISe(s)

Trials extracted from the podcast by Dr. Ken Milne

• 2015ProMISeICU & Critical CareIn 1260 adults with early septic shock in the emergency department, protocolised early goal-directed therapy did not reduce 90-day mortality versus usual care.
• 2014ProCESSICU & Critical CareIn 1341 ED patients with septic shock, protocol-based EGDT did not lower 60-day in-hospital mortality versus protocolized standard therapy or usual care.
• 2014ARISEICU & Critical CareIn1600 emergency department patients with early septic shock,early goal-directed therapydid not reduce90-day all-cause mortalitycompared withusual care.
• 2001Rivers EGDTICU & Critical CareIn263 emergency-department patients with severe sepsis or septic shock,six hours of early goal-directed therapyloweredin-hospital mortalitycompared withstandard therapy.
• 1816Dissertatio Medica Inauguralis de Synocho Castrensi (Inaugural Dissertation on Camp Fever)Infection & AntimicrobialsIn 366 soldiers with camp fever in the Peninsular War, withholding bloodletting lowered mortality compared with bloodletting.