SGEM#44: Pause (Etomidate and Rapid Sequence Intubation in Sepsis)

Ensayos extraídos del pódcast de Dr. Ken Milne

• 2012Etomidate is associated with mortality and adrenal insufficiency in sepsisICU & Critical CareIn 865 septic patients needing rapid sequence intubation, etomidate raised all-cause mortality and adrenal insufficiency versus other induction agents.
• 2010The Effect of a Bolus Dose of Etomidate on Cortisol Levels, Mortality, and Health Services UtilizationICU & Critical CareIn 1216 adults undergoing rapid sequence intubation, etomidate transiently lowered cortisol without increasing mortality compared with other induction agents.
• 2009CORTICUSICU & Critical CareIn 499 patients with septic shock, prior bolus etomidate was associated with more corticotropin non-response and higher 28-day mortality than no etomidate.
• 2004Early Lactate Clearance in Severe Sepsis and Septic ShockICU & Critical CareIn 111 emergency department patients with severe sepsis or septic shock, lactate clearance of at least 10% at 6 hours was associated with lower mortality than clearance below 10%.