SGEM #16: Ho, Ho, Hold the Proton Pump Inhibitor in Upper Gastrointestinal Bleed

Ensaios extraídos do podcast de Dr. Ken Milne

• 2010PPI treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleedingOtherIn 2223 patients with acute upper gastrointestinal bleeding, PPI before endoscopy did not reduce 30-day mortality, rebleeding or surgery versus placebo or H2-blocker.
• 1992Omeprazole versus placebo for acute upper gastrointestinal bleedingOtherIn 1147 patients with acute upper gastrointestinal bleeding, omeprazole did not reduce mortality, rebleeding or surgery compared with placebo.
• 2007Omeprazole before Endoscopy in Patients with Gastrointestinal BleedingOtherIn 638 patients with acute upper gastrointestinal bleeding, high-dose intravenous omeprazole before endoscopy reduced the need for endoscopic therapy at index endoscopy compared with placebo.