ANDROMEDA-SHOCK 2 Trial

Trials extracted from the podcast by Rob Mac Sweeney

• 2025ANDROMEDA-SHOCK-2ICU & Critical CareIn 1,501 patients with early septic shock, capillary refill time-targeted personalised resuscitation improved a hierarchical outcome of death, vital support and hospital stay compared with usual care.
• 2019ANDROMEDA-SHOCKICU & Critical CareIn 424 adults with early septic shock, capillary refill time-targeted resuscitation did not significantly reduce 28-day mortality compared with lactate-targeted resuscitation.
• 2010LACTATEICU & Critical CareIn ICU patients with lactate ≥3 mEq/L, lactate-guided resuscitation did not significantly reduce hospital mortality compared with standard care blinded to lactate.
• 2015PPTFMICU & Critical CareIn 30 ICU patients with septic shock, fluids guided by peripheral perfusion gave non-significantly less fluid and lower early SOFA scores than standard systemic haemodynamic targets.
• 2017Capillary refill time during fluid resuscitation in patients with sepsis-related hyperlactatemia at the EDEmergency & ResuscitationIn 95 ED patients with sepsis and hyperlactatemia, abnormal capillary refill after initial fluids predicted higher hospital mortality than normal capillary refill.
• 2020Effects of very early start of norepinephrine in patients with septic shockICU & Critical CareIn 186 matched patients with septic shock, very early norepinephrine was associated with lower 28-day mortality and less fluid compared with starting it after initial fluid loading.