Tigris Trial

Trials extracted from the podcast by Rob Mac Sweeney

• 2026TIGRISICU & Critical CareIn 157 adults with endotoxic septic shock and multiorgan dysfunction, polymyxin B haemoadsorption was associated with lower 28-day mortality than standard care alone.
• 2018EUPHRATESICU & Critical CareIn 450 adults with septic shock and elevated endotoxin activity, polymyxin B hemoperfusion did not reduce 28-day mortality compared with sham hemoperfusion.
• 2009EUPHASICU & Critical CareIn 64 patients with septic shock from intra-abdominal infection, polymyxin B haemoperfusion improved haemodynamics compared with conventional therapy alone.
• 2015ABDOMIXICU & Critical CareIn 243 patients with septic shock after surgery for peritonitis, polymyxin B hemoperfusion did not reduce 28-day mortality compared with conventional care.