PATCH-Trauma Trial Presentation

Essais extraits du podcast de Rob Mac Sweeney

• 2023PATCH-TraumaEmergency & ResuscitationIn 1310 severely injured adults at risk of trauma-induced coagulopathy, prehospital tranexamic acid did not improve 6-month functional outcome versus placebo.
• 2010CRASH-2Emergency & ResuscitationIn 20,211 trauma patients with or at risk of significant bleeding, tranexamic acid reduced all-cause mortality within 4 weeks compared with placebo.
• 2019CRASH-3Emergency & ResuscitationIn 12 737 adults with acute traumatic brain injury, tranexamic acid did not significantly reduce 28-day head injury-related death compared with placebo.
• 2020TAMPITIEmergency & ResuscitationIn 150 patients with severe traumatic bleeding, tranexamic acid did not reduce monocyte HLA-DR suppression at 72 hours compared with placebo.
• 2020HALT-ITEmergency & ResuscitationIn 12,009 adults with acute gastrointestinal bleeding, tranexamic acid did not reduce death due to bleeding but increased venous thromboembolism versus placebo.
• 2020Prehospital Tranexamic Acid Use for Traumatic Brain InjuryEmergency & ResuscitationIn 966 patients with moderate or severe traumatic brain injury, out-of-hospital tranexamic acid did not improve 6-month neurologic outcome versus placebo.