TAME Trial Presentation

Ensayos extraídos del pódcast de Rob Mac Sweeney

• 2023TAMEEmergency & ResuscitationIn 1700 comatose adults after out-of-hospital cardiac arrest, targeted mild hypercapnia did not improve 6-month neurological outcome versus targeted normocapnia.
• 2021TTM2Emergency & ResuscitationIn 1900 comatose adults after out-of-hospital cardiac arrest, targeted hypothermia at 33 °C did not reduce death at 6 months versus targeted normothermia.
• 2016CCCEmergency & ResuscitationIn 86 patients resuscitated from cardiac arrest, 24 h of targeted mild hypercapnia attenuated neuron-specific enolase release compared with targeted normocapnia
• 2013Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrestEmergency & ResuscitationIn 16,542 ICU patients admitted after cardiac arrest, hypercapnia was associated with more discharge home among survivors than normocapnia.
• 2016Cerebral oxygenation in mechanically ventilated early cardiac arrest survivorsEmergency & ResuscitationIn7 mechanically ventilated survivors of cardiac arrest,targeted mild hypercapniaraisedcerebral tissue oxygen saturationcompared withnormocapnia.
• 2018COMACAREEmergency & ResuscitationIn 123 comatose adults resuscitated from cardiac arrest, high-normal PaCO2 or moderate hyperoxia did not lower 48-h NSE versus low-normal PaCO2 or normoxia.
• 2017Association between arterial carbon dioxide tension and outcomes after cardiac arrestEmergency & ResuscitationIn patients after cardiac arrest, normocapnia was associated with higher hospital survival and good neurological outcome than hypocapnia or hypercapnia.
• 2022BOXEmergency & ResuscitationIn 789 comatose adults after out-of-hospital cardiac arrest, a restrictive oxygen target did not reduce death or severe disability versus a liberal target.
• 2022BOXEmergency & ResuscitationIn 789 comatose out-of-hospital cardiac arrest survivors, targeting a mean arterial pressure of 77 mm Hg did not reduce death or severe disability compared with 63 mm Hg.
• 2022EXACTEmergency & ResuscitationIn 428 adults after out-of-hospital cardiac arrest, targeting SpO2 90-94% did not improve survival to hospital discharge compared with 98-100%.
• 2025STEPCAREEmergency & ResuscitationIncomatose adults after out-of-hospital cardiac arrest,deep sedation, device fever control and higher MAPare compared withlighter targetsfor6-month mortality
• 2026LOGICALEmergency & ResuscitationIn 1840 ventilated adults unresponsive after cardiac arrest, conservative oxygen did not improve 180-day survival with favourable function versus liberal oxygen.