TTM2 Trial Presentation at CCR22

Ensayos extraídos del pódcast de Rob Mac Sweeney

• 2021TTM2Emergency & ResuscitationIn 1900 comatose adults after out-of-hospital cardiac arrest, targeted hypothermia at 33°C did not reduce 6-month mortality compared with targeted normothermia.
• 2022TTM/TTM2Emergency & ResuscitationIn 2800 comatose adults after out-of-hospital cardiac arrest, hypothermia at 33 degrees C did not reduce 6-month mortality compared with normothermia.
• 2013TTMEmergency & ResuscitationIn 950 comatose adults afterout-of-hospital cardiac arrest,targeted temperature management at 33°Cdid not reducemortalitycompared with36°C.
• 2002HACAEmergency & ResuscitationIn 275 comatose adults after ventricular-fibrillation cardiac arrest, 24 hours of mild hypothermia improved six-month neurologic outcome versus normothermia.
• 2002Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced HypothermiaEmergency & ResuscitationIn 77 comatose survivors of out-of-hospital ventricular fibrillation arrest, induced hypothermia improved survival with good neurologic outcome compared with normothermia.
• 2019HYPERIONEmergency & ResuscitationIn 581 comatose adults after nonshockable cardiac arrest, hypothermia at 33°C improved 90-day survival with good neurologic outcome compared with normothermia
• 2017TTH48Emergency & ResuscitationIn 355 comatose adults after out-of-hospital cardiac arrest, 48 hours of hypothermia at 33 °C did not improve 6-month neurologic outcome versus 24 hours.
• 2019PRINCESSEmergency & ResuscitationIn 677 out-of-hospital cardiac arrests, intra-arrest transnasal cooling did not improve 90-day neurologically intact survival over in-hospital cooling.
• 2018FROST-IEmergency & ResuscitationIn 150 comatose survivors of shockable out-of-hospital cardiac arrest, cooling to 32 °C did not improve 90-day neurologic outcome versus 33 °C or 34 °C.
• 2021CAPITAL CHILLEmergency & ResuscitationIn 367 comatose survivors of out-of-hospital cardiac arrest, hypothermia at 31 °C did not reduce death or poor neurologic outcome versus 34 °C.
• 1992A Critical Appraisal of 98.6°F, the Upper Limit of the Normal Body TemperatureOtherIn 148 healthy adults aged 18 to 40 years, serial oral thermometry placed the upper limit of normal at 37.7 °C rather than Wunderlich's 38.0 °C