CLASSIC Trial Results Presentation

Studi estratti dal podcast di Rob Mac Sweeney

• 2022CLASSICICU & Critical CareIn 1554 ICU patients with septic shock, restrictive intravenous fluid therapy did not reduce 90-day all-cause mortality compared with standard fluid therapy.
• 2016CLASSICICU & Critical CareIn 151 ICU patients with septic shock, a protocol restricting resuscitation fluid lowered fluid volumes at day 5 and in ICU compared with standard care.
• 2020Lower vs Higher Fluid Volumes During Initial Management of SepsisICU & Critical CareIn637 adults with sepsis,lower IV fluid volumesdid not reduceall-cause mortalitycompared withhigher fluid volumes.
• 2011FEASTICU & Critical CareIn 3170 African children with severe febrile illness and impaired perfusion, fluid boluses increased 48-hour mortality compared with maintenance fluids alone.
• 2017SSSP-2ICU & Critical CareIn 209 Zambian adults with sepsis and hypotension, an early fluid and vasopressor protocol increased in-hospital mortality compared with usual care.
• 2001EGDTICU & Critical CareIn 263 patients with severe sepsis or septic shock, six hours of early goal-directed therapy reduced in-hospital mortality compared with standard therapy.