The HOPE Trial Preliminary Results

Essais extraits du podcast de Rob Mac Sweeney

• 2022HOPEInfection & AntimicrobialsIn 416 healthcare workers, hydroxychloroquine plus PPE did not reduce laboratory-confirmed COVID-19 over 6 months compared with PPE alone.
• 2024PROVEPulmonary & AirwaysIn 132 non-critically ill patients with COVID-19, a passive non-invasive PEEP mask did not reduce respiratory rate compared with standard oxygen.
• 2021COVID STEROID 2ICU & Critical CareIn 1000 adults with COVID-19 and severe hypoxemia, higher-dose dexamethasone did not significantly increase days alive without life support at 28 days versus standard-dose dexamethasone.
• 2021REMAP-CAPICU & Critical CareIn 803 critically ill adults with Covid-19 on organ support, interleukin-6 receptor antagonists increased organ support-free days and survival compared with standard care.
• 2020PLACIDInfection & AntimicrobialsIn 464 adults hospitalised with moderate covid-19 in India, convalescent plasma did not reduce progression to severe disease or death versus standard care.
• 2021SolidarityInfection & AntimicrobialsIn 11,330 adults hospitalised with Covid-19, remdesivir, hydroxychloroquine, lopinavir or interferon beta-1a did not reduce in-hospital death vs standard care
• 2021Standard Care Versus Awake Prone Position in Adult Nonintubated COVID-19 PatientsICU & Critical CareIn 60 nonintubated adults with COVID-19 hypoxaemic respiratory failure, awake proning was feasible in a minority and did not reduce intubation vs standard care.