TTM2 Results Editorial

Studien extrahiert aus dem Podcast von Rob Mac Sweeney

• 2021TTM2Emergency & ResuscitationIn 1900 comatose adults after out-of-hospital cardiac arrest, hypothermia at 33°C did not lower 6-month all-cause mortality compared with targeted normothermia.
• 1991Mild Hypothermic Cardiopulmonary Resuscitation After Prolonged Cardiac Arrest in DogsEmergency & ResuscitationIn 30 dogs after 10 minutes of ventricular fibrillation, cooling to 34 °C during or right after CPR improved neurologic recovery compared with normothermia.
• 1997Clinical Trial of Induced Hypothermia in Comatose Survivors of Out-of-Hospital Cardiac ArrestEmergency & ResuscitationIn 44 comatose survivors of out-of-hospital cardiac arrest, 12 hours of moderate hypothermia improved good neurological outcome versus historical normothermia
• 2002Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced HypothermiaEmergency & ResuscitationIn 77 comatose survivors of out-of-hospital ventricular fibrillation arrest, cooling to 33 degrees C for 12 hours improved survival with good neurologic outcome compared with normothermia.
• 2002HACAEmergency & ResuscitationIn275 comatose adults resuscitated from ventricular fibrillation arrest,24 h of mild hypothermiaimproved6-month neurologic recoverycompared withnormothermia
• 2014Prehospital Induction of Mild Hypothermia After Cardiac ArrestEmergency & ResuscitationIn 1359 adults after out-of-hospital cardiac arrest, prehospital cold saline did not improve survival or neurologic status versus standard care.
• 2013TTMEmergency & ResuscitationIn 950 unconscious adults after out-of-hospital cardiac arrest, targeted temperature management at 33°C did not reduce mortality compared with 36°C.
• 2017Changing target temperature from 33 °C to 36 °C in out-of-hospital cardiac arrestEmergency & ResuscitationIn 76 patients after ventricular fibrillation cardiac arrest, a 36 °C temperature target was linked to worse temperature control and survival than 33 °C
• 2019PRINCESSEmergency & ResuscitationIn 677 patients with witnessed out-of-hospital cardiac arrest, intra-arrest trans-nasal cooling did not improve 90-day good neurologic survival versus usual care.