The Ventilator

Studien extrahiert aus dem Podcast von Rob Mac Sweeney

• 2024REMAP-CAPICU & Critical CareIn 200 ventilated adults with pneumonia and P/F <200, protocolised lung-protective ventilation is compared with clinician-preferred ventilation for 90-day mortality
• 2000ARMAICU & Critical CareIn 861 adults with acute lung injury or ARDS, ventilation at 6 mL/kg predicted body weight reduced mortality compared with 12 mL/kg.
• 2004ALVEOLIICU & Critical CareIn 549 patients with acute lung injury and ARDS, a higher-PEEP/FiO2 table did not reduce in-hospital mortality compared with the lower-PEEP ARDSNet table.
• 2016LUNG SAFEICU & Critical CareIn 2377 ICU patients with ARDS in 50 countries, routine ventilation fell short of lung-protective targets, with 40% hospital mortality
• 2019PHARLAPICU & Critical CareIn 115 adults with moderate-to-severe ARDS, maximal lung recruitment with titrated PEEP did not increase ventilator-free days versus ARDSNet ventilation.
• 2020RELAxICU & Critical CareIn 980 ICU patients without ARDS, a lower PEEP strategy was noninferior to a higher PEEP strategy for ventilator-free days at day 28.
• 2019ROSEICU & Critical CareIn 1006 adults with moderate-to-severe ARDS, early cisatracurium with deep sedation did not reduce 90-day mortality versus usual care with lighter sedation