CCR19 Day 1 Trials Panel Discussion

Ensayos extraídos del pódcast de Rob Mac Sweeney

• 2018APROCCHSSICU & Critical CareIn 1241 adults with septic shock, hydrocortisone plus fludrocortisone reduced 90-day all-cause mortality compared with placebo.
• 2010COIITSSICU & Critical CareIn 509 adults with septic shock treated with hydrocortisone, adding fludrocortisone did not lower in-hospital mortality compared with hydrocortisone alone.
• 2018SMARTICU & Critical CareIn 15,802 critically ill adults, balanced crystalloids reduced major adverse kidney events within 30 days compared with saline.
• 2018SALT-EDEmergency & ResuscitationIn 13,347 non-critically ill adults given intravenous fluids in the emergency department, balanced crystalloids did not increase hospital-free days versus saline.
• 2018MIND-USAICU & Critical CareIn 566 critically ill patients with delirium, haloperidol and ziprasidone did not increase days alive without delirium or coma compared with placebo.
• 2022AID-ICUICU & Critical CareIn1000 ICU patients with delirium,haloperidoldid not increasedays alive and out of hospital at 90 dayscompared withplacebo.
• 2018AI ClinicianICU & Critical CareIn 96,156 septic ICU admissions, dosing matching the AI Clinician's policy was associated with lower mortality than clinicians' divergent dosing.
• 2019POPPIICU & Critical CareIn 1458 critically ill ICU patients, a nurse-led preventive psychological intervention did not reduce PTSD symptom severity at 6 months compared with usual care.
• 2019ANDROMEDA-SHOCKICU & Critical CareIn 424 adults with septic shock, resuscitation targeting capillary refill time did not significantly reduce 28-day mortality compared with lactate-targeted resuscitation.